Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation.
نویسندگان
چکیده
[reaction: see text] A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and aldehydes in the presence of NH(4)OAc is described. Under microwave irradiation, alkyl-, aryl-, and heteroaryl-substituted imidazoles are formed in yields ranging from 80 to 99%. Short syntheses of lepidiline B and trifenagrel illustrate the utility of this approach.
منابع مشابه
Improving methodology for the preparation of highly substituted imidazoles using nano-MgAl2O4 as catalyst under microwave irradiation
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ورودعنوان ژورنال:
- Organic letters
دوره 6 9 شماره
صفحات -
تاریخ انتشار 2004